Cefoperazone Injection

Product Description

Cefoperazone 0.5mg is of Semi Synthetic origin and belongs to Cephem Carboxylate. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-3rd Gen pharmacological group.


Mechanism of action:

Cefoperazone, a third generation Cephalosporin acts by inhibiting biosynthesis of cell wall mucopeptide. Sulbactam acts a beta-lactamase inhibitor, thus restoring Cefoperazone activity against beta-lactamase producing strains.

Pharmacology: 

• Absorbtion: The mean serum concentration obtained at 30 min after 1 g I.V. Cefoperazone is 114 mcg/ml. The mean serum concentration obtained at 15 min. after 500 mg and 1000 mg IV Sulbactam are 21-40 mcg/ml and 48-88 mcg/ml respectively. The average peak plasma concentration at 5 minutes after intravenous dose of 1g is 81mg/litre. Distribution: The protein binding of Cefoperazone is 82-93% and that of Sulbactam is 38%.
• Metabolism and Excretion: No significant quantity of metabolites of Cefoperazone has been found in the urine. Cefoperazone is excreted mainly in the bile. About 75-85% of Sulbactam is excreted in the urine during the first eight hours of administration.
• Indications: Monotherapy Sulbactam/ Cefoperazone is indicated for the treatment of the following infections when caused by susceptible organisms:– Respiratory Tract Infections (Upper and Lower)– Urinary Tract Infections (Upper and Lower)– Peritonitis, Cholecystitis, Cholangitis, and Other Intra-Abdominal Infections– Septicemia– Meningitis– Skin and Soft Tissue Infections– Bone and Joint Infections– Pelvic Inflammatory Disease, Endometritis, Gonorrhea, and Other Infections of the Genital Tract

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